epitalon comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2026-01-16. Where a claim depends on a specific study, the study is described rather than over-claimed.
Residue composition is the property that most cleanly separates verified material from mislabelled samples. Alanine, glutamate, aspartate and glycine appear in that order from the N-terminus, and the two acidic residues sit in the middle of the chain. Because the peptide is short, it can be produced by solid-phase synthesis and characterised by mass spectrometry without ambiguity. Any reported sample whose measured mass departs substantially from 390 daltons is a different compound or a degraded mixture rather than epitalon.
Epitalon is a synthetic tetrapeptide whose four residues are alanine, glutamate, aspartate and glycine, commonly abbreviated AEDG. Its molecular formula is C14H22N4O9 and its monoisotopic mass is near 390.35 daltons. The peptide carries two acidic side chains, so it is neutral to negatively charged in most aqueous buffers. Published reference summaries usually list it under both spellings, epitalon and epithalon, and treat the two names as the same material.
Published work on this compound consists mainly of in vitro experiments, animal studies, and small clinical investigations, a substantial share of which appeared in Russian-language journals. Sample sizes are generally small, control conditions differ between studies, and several endpoints rely on markers whose clinical meaning is itself debated. Reviews of the longevity field treat the peptide as an early example of telomerase-directed research rather than an established intervention. Regulatory treatment varies by country: some jurisdictions place it under prescription controls, others treat it as a laboratory material, and importation may be restricted regardless of local status.
Epitalon is a synthetic tetrapeptide whose sequence is alanine–glutamate–aspartate–glycine, commonly abbreviated AEDG. It was developed in Russia during the 1980s and 1990s by investigators associated with the St. Petersburg Institute of Bioregulation and Gerontology, who studied short peptides as regulators of gene expression and tissue function. The alternative spelling epithalon appears interchangeably in the literature, and the two names refer to the same molecule. Outside Russia it is encountered chiefly as a research chemical rather than a licensed medicine, and it holds no approval from the United States Food and Drug Administration or the European Medicines Agency.
| Property | Value | Notes |
|---|---|---|
| Molecular formula | C14H22N4O9 | Derived from the four constituent residues |
| Molecular mass | About 390.35 Da | Monoisotopic value, confirmed by mass spectrometry |
| Residue sequence | Ala-Glu-Asp-Gly | Read from the N-terminus to the C-terminus |
| Common synonyms | Epithalon; AEDG | Both forms appear in reference catalogues |
| Net charge near neutral pH | Negative | Two acidic side chains give a low isoelectric point |
Several names circulate for the same molecule, including epitalon, epithalone, epithalamin tetrapeptide, and the sequence code AEDG. A CAS registry number, 307297-39-8, is commonly cited for it, though catalogue entries should be checked against supplier documentation because mislabelled records occur. In its usual form the peptide carries free amino and carboxyl termini and is neither glycosylated nor lipidated. Researchers distinguish the defined tetrapeptide from epithalamin itself, a crude pineal preparation containing many peptides that is not chemically characterised.
Material supplied for laboratory use is normally a lyophilised white to off-white powder that dissolves readily in water and in isotonic saline. Lyophilised cakes are hygroscopic and should be equilibrated to room temperature before opening to limit condensation on the solid. Solutions are typically prepared at milligram-per-millilitre concentrations and divided into single-use aliquots, because repeated freeze–thaw cycles degrade short peptides. Aqueous solutions are far less stable than the dry powder, and identity is usually verified by mass spectrometry alongside purity estimation from reversed-phase high-performance liquid chromatography.
Epitalon is a synthetic linear tetrapeptide with the sequence alanine–glutamate–aspartate–glycine, abbreviated AEDG. Its molecular formula is C14H22N4O9 and the calculated mass is approximately 390.35 g/mol. The compound is made by solid-phase peptide synthesis rather than extracted from tissue, although early work described it as a short fragment of a peptide fraction obtained from bovine pineal extract. In the research literature the spelling epitalon and the variant epithalone both appear, while AEDG is the standard code used in peptide nomenclature.
Epitalon is a synthetic tetrapeptide whose sequence is alanine-glutamate-aspartate-glycine, written in single-letter code as AEDG. The four residues are joined by three peptide bonds, giving a linear backbone with no branching and no disulfide bridges. Its calculated molecular mass for the free form is approximately 390.3 daltons, a figure that rises when the compound is supplied as an acetate or trifluoroacetate salt. Because the chain is short, the molecule is defined entirely by its residue order rather than by any folded three-dimensional structure.
The compound is described in the literature as a derivative of epithalamin, a preparation obtained from bovine pineal tissue. Work on this peptide family was carried out mainly by a research group in Saint Petersburg beginning in the 1980s, and the substance was later registered for clinical use in Russia under the name Epitalon. Outside that region it is generally treated as a research chemical rather than an approved medicine. Statements about its biological activity rest on a relatively small number of studies, and independent replication remains limited.
=== Criticism of expert witnesses === Several medical experts have questioned the reliability of the prosecution's expert witness, Dewi Evans. Svilena Dimitrova, an NHS consultant neonatologist, and Roger Norwich, a medico-legal expert, submitted formal complaints to the General Medical Council regarding Evans's evidence. Dimitrova told The Guardian that she believed "the theories proposed in court were not plausible and the prosecution was full of medical inaccuracies", adding that while she could not assert Letby's innocence, she saw "no proof of guilt". Evans rejected suggestions of bias and noted that the defence could have called its own expert witnesses at trial but did not do so. Other prosecution experts broadly supported Evans' conclusions. The New Yorker reported that in an unrelated earlier case, a Court of Appeal judge had described one of Evans's expert reports as "worthless", containing opinions that were "tendentious and partisan" and outside his professional competence. Another paediatrician who testified as an expert for the prosecution has since resigned from her position as a consultant following multiple complaints about her practice. The prosecution's endocrinologist, Peter Hindmarsh, was under investigation by the General Medical Council (GMC) when he gave evidence during the trial. The investigation was prompted by "multiple and wide-ranging concerns" about his practice from both of the hospitals he was affiliated with. A medical tribunal placed restrictions on his ability to practise, arguing that he "may pose a real risk to members of the public".
Ethanol (alcohol) reduces the calcium-dependent secretion of AVP by blocking voltage-gated calcium channels in neurohypophyseal nerve terminals in rats. Angiotensin II stimulates AVP secretion, in keeping with its general pressor and pro-volumic effects on the body. Atrial natriuretic peptide inhibits AVP secretion, in part by inhibiting Angiotensin II-induced stimulation of AVP secretion. Cortisol inhibits secretion of antidiuretic hormone.
The families of two missing people from Trinidad and Tobago identified them publicly and suspected they were killed in the 14 October strike; one family said their relative was a fisherman who traveled often to Venezuela and denied he was involved in trafficking drugs. MSNBC wrote that one had a drug-related charge from 2018, and the other had been released in 2021 after a prison sentence for a 2009 murder. In the Paria Peninsula of Sucre state in Venezuela, from which the first boat struck on 1 September allegedly originated, Venezuelan media reported the area was known for trafficking, although not necessarily by Tren de Aragua, and some family members stated that villagers had become involved in illicit activity out of economic necessity. Inhabitants describing a town in mourning published tributes containing photos of the deceased beginning early on 3 September. The deceased included eight persons from San Juan de Unare and three from a nearby town, Güiria. The New York Times reported that "Venezuelan security officials descended on San Juan de Unare, cut off the electricity and made clear that public pronouncements about the attacks were not welcome, according to four townspeople, including the niece of one of the victims." Associated Press journalist Regina Garcia Cano visited Sucre just after the first Venezuelan strike and interviewed dozens of people; she wrote of the "sources' very real fears of being punished—particularly by the Venezuelan government—for speaking to reporters".
== Biosynthesis == Its complete biosynthetic pathway includes glycolysis, the tricarboxylic acid (TCA) or citric acid cycle (Krebs cycle), and the aspartate metabolic pathway. It forms by two reductions of aspartic acid via the intermediacy of aspartate semialdehyde. Specifically, the enzyme homoserine dehydrogenase, in association with NADPH, catalyzes a reversible reaction that interconverts L-aspartate-4-semialdehyde to L-homoserine. Homoserine kinase and homoserine O-succinyltransferase convert homoserine to phosphohomoserine and O-succinyl homoserine, respectively. Homoserine is produced from aspartate via the intermediate aspartate-4-semialdehyde, which is produced from β-phosphoaspartate. By the action of homoserine dehydrogenases, the semialdehyde is converted to homoserine.
== Recognition and sustainability == TCI has publicly promoted sustainability initiatives and in recent years participated in corporate sustainability networks. Industry reporting and chamber notices noted TCI's membership in RE100 initiatives or climate/sustainability collaborations, positioning the company among early adopters in Taiwan's biotech/manufacturing sector to commit to renewable energy targets and net-zero ambitions.
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==== 5-HT2 receptor ==== Antagonism of the 5-HT2 subfamily of receptors and inverse agonism of the 5-HT2C receptor appears to be in part responsible for mirtazapine's efficacy in the treatment of depressive states. Mirtazapine increases dopamine release in the prefrontal cortex. Accordingly, it was shown that by blocking the α2-adrenergic receptors and 5-HT2C receptors mirtazapine disinhibited dopamine and norepinephrine activity in these areas in rats. In addition, mirtazapine's antagonism of 5-HT2A receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor. Mirtazapine has been shown to lower drug seeking behaviour (more specifically to methamphetamine) in various human and animal studies. It is also being investigated in substance abuse disorders to reduce withdrawal effects and improve remission rates. Mirtazapine significantly improves pre-existing symptoms of nausea, vomiting, diarrhea, and irritable bowel syndrome in affected individuals. Mirtazapine may be used as an inexpensive antiemetic alternative to Ondansetron. In conjunction with substance abuse counseling, mirtazapine has been investigated for the purpose of reducing methamphetamine use in dependent individuals with success.
=== Cosmetics with donkey milk === In recent years, the cosmetic industry has focused on products made with natural ingredients, and is oriented towards sustainable consumption. Because of their natural origin, milk components correspond in many fields to the needs of the cosmetics industry. A recent scientific study on a cream containing lyophilized donkey milk showed different benefits for the skin. These results are related to the effectiveness of donkey milk components like proteins, minerals, vitamins, essential fatty acids, bioactive enzymes, and coenzymes which provide balanced nourishment and proper hydration for the skin. In particular vitamin C content in donkey milk is almost 4 times more of cow's milk. Since donkey milk contains more lactoferrin than cows milk, and a considerable amount of lysozyme, it has the potential, when properly formulated, to reduce skin problems such as eczema, acne, psoriasis, and herpes by calming the irritation symptoms as reported by some authors. Some authors have preliminarily evaluated whether the use of a face cream made from donkey milk affected the perception of some sensory aspects. The results showed that treated cream was appreciated by dry skin consumers for the following sensory aspects: spreadability, total appearance, smoothness, moisturisation, and total effectiveness. The overall judgement also resulted highest for face cream made with donkey milk. Donkey milk is used in the manufacture of soaps and creams.
At the moment that each or every one of them is caught, whatever the circumstances, this resolution will be executed, without giving rise to minutes that provide requests and relationships capable of compromising compliance with this order and the honor of Your Excellency. This punishment must be the basis of the stability of the new system and a lesson for the chiefs of Peru, who advance to a thousand excesses for the hope of impunity and is at the same time the proof of the usefulness and energy with which this Expedition fills the important objects what is it intended for." There were also signs of Peruvian-phobia on the part of the Argentines of the Junta when Manuel Belgrano exposed on July 6, 1816, in front of the deputies of the Congress of Tucumán in two meetings, a proposal to establish an almost nominal monarchy, discussing first about choosing a European prince and then a Peruvian sovereign from the descendants of the Incas to offer the throne, it was most likely projected that the title would correspond to Juan Bautista Túpac Amaru, the only known surviving brother of the Inca noble, Túpac Amaru II, although they also considered Dionisio Inca Yupanqui, a mestizo jurist and soldier who had been educated in Europe and who was the representative of Peru at the Cortes of Cádiz, or Juan Andrés Jiménez de León Manco Cápac, a mestizo cleric and soldier who earned his fame for opposing the excessive collection of tribute and that he participated as a military commander in the uprising of Juan José Castelli.
== Education and professional development == The HGSA oversees professional training and certification in the fields of Diagnostic Genomics and Genetic Counseling. Two Boards of Censors oversee training in these two respective fields. The HGSA partners with the Royal College of Pathologists of Australasia to train senior diagnostic genomicists to become Fellows of the Faculty of Science. The Australasian Association of Clinical Geneticists (AACG), a Special Interest Group of the HGSA, has direct ties with the Royal Australasian College of Physicians (RACP), which is the body that oversees training and accreditation in clinical genetics in Australasia. The AACG advises the RACP on curricula and training requirements. In addition, members of the AACG supervise the clinical training of RACP trainees in clinical genetics. The AACG also oversees a lecture series for clinical genetics trainees. The HGSA hosts a large number of educational events throughout the year to help members undertake continuing professional development. In addition to the Society's Annual Scientific Meeting, members have access to a large number of webinars that are broadcast across Australia and New Zealand. Furthermore, each Branch holds face-to-face educational activities, such as lectures and symposia, for local members.
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In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the effect of grapefruit on the metabolism of drugs. Interactions may occur by simultaneous targeting of receptors, directly or indirectly. For example, both Zolpidem and alcohol affect GABAA receptors, and their simultaneous consumption results in the overstimulation of the receptor, which can lead to loss of consciousness. When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. Drug interactions can be of three kinds:
The former Trump Plaza hotel in Atlantic City, New Jersey is demolished in a controlled implosion. The U.S. Food and Drug Administration approves the Patient Specific Talus Spacer 3D-printed talus implant for humanitarian use. The Patient Specific Talus Spacer is the first in the world and first-of-its-kind implant to replace the talus—the bone in the ankle joint. February 18 – NASA successfully lands its Perseverance rover on Mars, seven months after launching. February 19 – The U.S. officially rejoins the Paris Agreement, 107 days after leaving. February 22 New York Rangers winger Artemi Panarin takes a personal leave of absence after the Russian tabloid Komsomolskaya Pravda publishes a story in which former Kontinental Hockey League coach Andrei Nazarov accuses him of sexually assaulting an 18-year old Latvian woman in Riga. The team releases a statement calling the allegations against Panarin an "intimidation tactic" against him after speaking out against "recent political events", most notably expressing his support for Russian opposition leader Alexei Navalny, who was detained upon return to Russia from Germany. Enabling legislation for New Jersey Public Question 1 is signed into law by governor Phil Murphy, making New Jersey the 14th state to legalize recreational cannabis. The Supreme Court rejects a last-ditch attempt by Donald Trump to shield his financial records, and issues an order requiring his accountants to turn over his tax and other records to prosecutors in New York.
=== Pump pressure === Pumps vary in pressure capacity, but their performance is measured on their ability to yield a consistent and reproducible volumetric flow rate. Pressure may reach as high as 60 MPa (6000 lbf/in2), or about 600 atmospheres. Modern HPLC systems have been improved to work at much higher pressures, and therefore are able to use much smaller particle sizes in the columns (<2 μm). These "ultra high performance liquid chromatography" systems or UHPLCs, which could also be known as ultra high pressure chromatography systems, can work at up to 120 MPa (17,405 lbf/in2), or about 1200 atmospheres. The term "UPLC" is a trademark of the Waters Corporation, but is sometimes used to refer to the more general technique of UHPLC.
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It is a four-amino-acid peptide built from alanine, glutamate, aspartate and glycine in that order. Its formula is C14H22N4O9, and it is made by chemical synthesis rather than extracted from tissue. The synthetic peptide is a single defined molecule, unlike the pineal extracts it is often compared with.
No. The two spellings refer to the same tetrapeptide, and the difference reflects transliteration from Russian. Laboratories and catalogues use both forms interchangeably. The material is also indexed as AEDG, taken from the one-letter codes of its residues.
Epithalamin is a mixed preparation derived from animal pineal tissue and contains many peptides. Epitalon is one synthetic sequence chosen for study from that broader mixture. Statements about one do not transfer directly to the other.
Epitalon is a synthetic four-amino-acid peptide with the sequence alanine–glutamate–aspartate–glycine, also written AEDG. It was developed in Russian gerontology research and is studied for proposed effects on telomerase, melatonin regulation, and neuroendocrine function. It is not an approved pharmaceutical in the United States or the European Union.